Direct enzymatic route for the preparation of novel enantiomerically enriched hydroxylated beta-amino ester stereoisomers.
نویسندگان
چکیده
Enantiomerically enriched hydroxy-substituted beta-amino esters have been synthesized through CAL-B-catalyzed enantioselective hydrolysis in organic media. Moderate to good enantiomeric excess values (ee > or = 52%) were obtained when the CAL-B-catalyzed reactions were performed in t-BuOMe, at 60 degrees C with 0.5 equiv. of added H(2)O as nucleophile.
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عنوان ژورنال:
- Molecules
دوره 15 6 شماره
صفحات -
تاریخ انتشار 2010